However, transcriptomic changes in the brainstem, were minimal between PBM-deficient and E-WT virus infections, with the identification of three PDZ-related proteins: CNKSR2, which features both a PBM and a PDZ domain [101], as well as SGK1, recognized for its interaction with the PDZ-containing NHERF family [102] previously reported as a partner of the E PBM [28], and ERBIN, a basolateral epithelial protein [103] related to Ras-Raf and NF-kB signaling pathways [104–107]. The gene discussed is CNKSR2; the disease is viral infectious disease.