SP100 and primary biliary cholangitis: Primary Biliary Cholangitis (PBC) is an autoimmune liver disease distinguished by high titer positive Anti-mitochondrial Antibodies (AMAs) and specific antinuclear antibodies (anti-sp100, anti-gp210), small intrahepatic bile duct injury, cholestasis, progressive liver fibrosis, and eventually decompensated liver cirrhosis [1].