IDO1 and familial pancreatic carcinoma: Li et al. constructed a Sono-activatable semiconducting polymer nanoreshapers (SPNDNH) loaded with an IDO inhibitor (NLG919) and modified with hyaluronidase, which could be used as an anti-inflammatory agent for the treatment of cancer, promoting nanoparticle enrichment and immune cell infiltration by degrading abundant HA in the pancreatic cancer ECM, and also blocking IDO activity by NLG919, remodeling the tumor immune microenvironment, as well as the tumor immune microenvironment, tumor in situ growth and distant metastasis were suppressed in a mouse model of pancreatic cancer [283].