CSF1R and neoplasm: Compared to the Csf1r+/+ BMMs, which secreted VEGF-A in both the co-culture system and when cultured in tumor cell conditioned media (Fig. 3C, D), Csf1r−/− BMMs did not significantly secrete VEGF-A, in either a co-culture system with MDA-MB-231 tumor cells, or when cultured with medium conditioned by the tumor cells (Fig. 3C, D).