MEG3 and hypertrophic cardiomyopathy: In addition, MEG3 overexpression activated pathways such as “pantothenate and coa biosynythesis”, “homologous recombination”, “propanoate metabolism” and “valine leucine and isoleucine biosynthesis”, whereas its downregulation activated pathways such as “glycosaminoglycan biosynthesis keratan sulfate”, “dilated cardiomypathy”,“arrhythmogenic right ventricular cadiomyopathy”, “WNT signaling pathway”, “NOTCH signaling pathway”, “basal cell carcinoma” and “hypertrophic cardiomyopathy”.