Tumour-associated macrophages (TAMs) exhibit complex phenotypes, thereby the transcriptomic diversity of TAMs, such as interferon-primed TAMs (IFN-TAMs, high expression of IFN-regulated genes and M1-like markers), inflammatory cytokine-enriched TAMs (Inflam-TAMs, enriched with inflammatory cytokines), lipid-associated TAMs (LA-TAMs, characterized by canonical M2-like pathways, fatty acid metabolism and immunosuppression) and immune regulatory TAMs (Reg-TAMs, high expression of T cell suppression and immune checkpoints [ICs]), has been reviewed via scRNA-seq cancer studies [18]. Here, IFNA1 is linked to cancer.