Apart from advanced age (> 65 years) and carrying one or two APOE ε4 alleles being the strongest risk factors (van der Lee et al. 2018b, a), type 2 diabetes (T2DM), obesity, and mild cognitive impairment (MCI) are well accepted risk factors for developing dementia and especially the sporadic form of AD (sAD) (Livingston et al. 2024) accounting for over 95% of AD cases (Masters et al. 2015). The gene discussed is APOE; the disease is Alzheimer disease.