Whereas LIR significantly improved the memory ability and neurological dysfunction of Sevoflurane-treated rats, a model of postoperative cognitive function (Hu et al. 2024) and of APP/PS1 mice, a model for the familial form of AD (McClean et al. 2011; for review: Wicinski et al. 2019), we were not able to show that LIR reverses this deteriorating STZ-icv-effect, e.g. by reducing the number of errors. The gene discussed is APP; the disease is Alzheimer disease.