GCG and Insulin resistance: As treatment with the GLP-1 analogue LIR, on the other hand, is proposed to have an attenuating effect on neuroinflammation, and as inflammation and brain insulin resistance affect the other in a positive feedback loop, our results of a promoting effect of LIR on Il1b and Il6 expression in the STZ-icv treated groups in the PFC and of a general reinforcing effect on Il6 expression in the hypothalamus were unexpected.