In the present study, we examined how baselinies plasma levels of CD20+ extracellular vesicles (EVs) relate to these previously characterized biomarkers of AIDS-NHL, such as IL-10, CXCL13, IL-10, BAFF, sCD14, sTNF-RII, sIL-2Rα/sCD25, IL-18, and CCL12-MCP-129–31. Here, IL18 is linked to AIDS.