Baseline plasma levels of extracellular vesicles bearing CD20 are associated with plasma levels of biomarkers of B-cell activation and differentiation (sCD27, CXCL13, sIL-2Rα/sCD25, sTNF-RII), macrophage activation (sCD163, IL-18), and microbial translocation (LBP, EndoCab IgM) in patients with AIDS-NHL. Here, LBP is linked to non-Hodgkin lymphoma.