PTEN and non-Hodgkin lymphoma: For example, research shows that exosomes isolated from plasma of B-cell lymphoma patients carry mRNA of oncogenes (cMYC, BCL-6, BCL-XL), the tumor suppressors PTEN, and important signaling pathway molecules (NF-kβ, AKT) dysregulated in NHL, which may serve as prognostic markers of lymphomagenesis65.