Furthermore, CD20+ EVs showed significant positive correlations with potential prognostic biomarkers of AIDS-NHL29,30,40,41 at baseline: sCD27, CXCL13, sIL-2Rα/sCD25, sTNF-RII, sCD163, IL-18, LBP, and EndoCab IgM. The gene discussed is CD40LG; the disease is AIDS.