Significant associations were observed between baseline plasma levels of CD20+ EVs and baseline plasma levels of prognostic biomarkers of AIDS-NHL: sCD27, CXCL13, sIL-2Rα/sCD25, sTNF-RII, sCD163, IL-18, LBP, and EndoCab IgM. This evidence concerns the gene CD40LG and non-Hodgkin lymphoma.