The characteristic of Cd24a-Hmga2 co-expression in the murine model could to some extent be observed in the KMT2A::AFF1 infants, and is interesting from a therapeutic perspective, where knockdown of HMGA2 reduced proliferation of KMT2A::AFF1 ALL cell lines [45]. The gene discussed is HMGA2; the disease is acute lymphoblastic leukemia.