In this study, we employed SM-pull down coupled with liquid chromatography tandem-mass spectrometry (LC–MS/MS) to identify two peroxidases, PRDX1 and PRDX2 (Peroxiredoxin 1 and 2) as the immediate protein targets of ART in DLBCL cells. The gene discussed is PRDX2; the disease is diffuse large B-cell lymphoma.