In the overall sample, following adjustments for age, sex, education, and APOE4 carrier status, DTI-ALPS (p < 0.001) was significantly lower and CPV (p < 0.001), PSMD (p < 0.001), and NLR (p = 0.035) were significantly higher in participants with AD than SCD. Here, APOE is linked to Schnyder corneal dystrophy.