Moreover, 4-PBA abrogated CHOP induction in response to regorafenib (Fig. S3e), and promoted the cleavages of caspase 3 and GSDME (Figs. 3h and S3f) and enhanced regorafenib cytotoxicity in both human (Fig. 3i) and murine HCC cells (Figs. 3j and S3g). This evidence concerns the gene DDIT3 and hepatocellular carcinoma.