GSDME and hepatocellular carcinoma: Moreover, 4-PBA abrogated CHOP induction in response to regorafenib (Fig. S3e), and promoted the cleavages of caspase 3 and GSDME (Figs. 3h and S3f) and enhanced regorafenib cytotoxicity in both human (Fig. 3i) and murine HCC cells (Figs. 3j and S3g).