In order to study the relevance of TIM3 during metastasis, we tested the metastatic ability of TIM3 gain- and loss-of-function in different mouse strains using 4T07, 4T1, and AT3 tumor cells, with Balb/c and C57BL/6 origin, respectively, with different immunity.34 This evidence concerns the gene HAVCR2 and neoplasm.