In order to capture the initial events of metastasis seeding of TIM3+ cells in our models, we monitored 4T07-FLuc-GFP cells by BLI imaging at 0, 6 h, and 3 days after i.c. systemic delivery, showing tumor cells distributed in different organs after 6 h (Figures S4A and S4B). The gene discussed is HAVCR2; the disease is neoplasm.