,80 Mechanistically, we show TIM3/β-catenin signaling in our transcriptomic analyses and validations, in consonance with the TIM3 activation of AKT/β-catenin signaling in myeloid leukemia cells,20,47 and interaction with P85 (PI3KR1),15 which is known to inactivate the β-catenin inhibitor GSK3-β.81 This evidence concerns the gene AKT1 and myeloid leukemia.