The unexpected expression of TIM3 in breast tumor cells found in this study is in consonance with other studies showing expression of TIM3 in malignant cells in diffuse intrinsic pontine glioma (DIPG),21 although the TIM3 blockade effects were mainly occurring in immune-TIM3+ microglia and macrophages causing major proinflammatory effects. Here, HAVCR2 is linked to diffuse intrinsic pontine glioma.