However, TIM3 expression is not only restricted to immune cells, and recent studies have reported TIM3 expression in normal epithelial cells and tumor cells,19 including leukemia stem cells20 and diffuse intrinsic pontine glioma (DIPG)21 triggering AKT and β-catenin signaling. This evidence concerns the gene AKT1 and diffuse intrinsic pontine glioma.