TIM3 expression was confirmed to be expressed in tumor cells by co-localization with mammaglobin (MGB1), a marker of breast cancer epithelial cells,36 detected by immunofluorescence (IF), and by IHC TIM3 staining of 75 patients samples with primary-metastasis matched tissues from the ConvertHER cohort37 (NCT01377363) (Figure 2H). This evidence concerns the gene HAVCR2 and breast cancer.