ZMPSTE24 and Emery-Dreifuss muscular dystrophy: The final cohort included the following diagnostic categories: eight patients (Cases 1–8) with HGPS (definite diagnosis); two patients (Cases 9 and 10) with HGPS (uncertain diagnosis); two patients (Cases 11 and 12) with ZMPSTE24 deficiency; three patients (Cases 13–15) with Emery-Dreifuss muscular dystrophy (EDMD); and one patient (Case 16) with congenital muscular dystrophy (CMG) (Figure 1 and Supplementary Table 1).