ZMPSTE24 and Hutchinson-Gilford progeria syndrome: Four patients with definite HGPS and eight with progerin-related PL (definite HGPS, n = 4; uncertain HGPS, n = 2; and ZMPSTE24 deficiency, n = 2) were reported alive in October 2023, and the estimated Japanese population was 124,352,000 in 2023.