As our immune system plays a crucialrole in many different diseases,immunotherapy using cytokines has been extensively explored as a potentialtreatment strategy.−,  Cytokines currently used in the clinic include interferonα and interleukin 2 (IL2). While successfully applied in the treatmentof autoimmune diseases and cancer, their use is associated with seriousadverse effects, such as hematological toxicity, arrhythmias, andchest pain., These adverse effects are primarilycaused by two factors: cytokines’ poor pharmacokinetic profile and their pleiotropic nature.,, The gene discussed is IL2; the disease is cancer.