NFKB1 and atherosclerosis: Intermittent hypoxia and repeated hypoxia/reoxygenation cycles induce oxidative stress, reactive oxygen species (ROS) production, activation of NF-κB, elevated expression of pro-inflammatory cytokines and chemokines, and M1-type macrophage recruitment and infiltration in different tissues, such as the vasculature and the heart, which ultimately leads to vascular remodelling, metabolic dysfunction and atherosclerosis [32].