The KEGG enrichment of the samples involved in GSEA indicated that the control group had a higher correlation with adipocytokine signaling pathway, cardiac muscle contraction, dilated cardiomyopathy, hypertrophic cardiomyopathy hcm, insulin signaling pathway (Fig 5A), while pathways such as allograft rejection, cell adhesion molecules cams, chemokine signaling pathway, cytokine cytokine receptor interaction, leishmania_infection were enriched in the RA group (Fig 5B). This evidence concerns the gene INS and dilated cardiomyopathy.