MAPT and early-onset autosomal dominant Alzheimer disease: Our study extends use of the DGRP to identify genes associated with complex neurodegenerative disease-related traits which has previously included retinal degeneration in retinitis pigmentosa (Chow et al. 2016), Amyloid β and tau toxicity in a model of Alzheimer's disease (Yang et al. 2023) and mutant LRRK2 G2019S-related locomotor deficits in a model of PD (Lavoy et al. 2018).