In contrast, a previous analysis using advanced MRI-based tumor volume assessment by multiplanar segmentation could show a significant correlation of tumor volume and axonal degradation measured by retinal layer fiber layer (RFNL) thickness, while two subsequent studies analyzing the impact of several MRI radiomic features could show a correlation of tumor volume, assessed by (semi-)automated segmentation-based volumetry, on VA loss in NF1-associated and non-NF1-OPG [20–22]. The gene discussed is NF1; the disease is neoplasm.