Further linear regression analyses to evaluate a possible correlation between tumor volume at diagnosis and further deterioration in VA during follow-up, measured by logMAR change of any eye, showed a minor, thus significant correlation both when including all patients and considering cases with NF-1 OPG (R2 = 0.22, p = 0.01 and R2 = 0.39, p = 0.01, respectively, see Fig. 3C). This evidence concerns the gene NF1 and neoplasm.