Healthy stem cells do not have a deficiency in ALDH1A1 activity, and they express ALDH1A1 in high levels at both the RNA and protein levels when compared to AML cells [12,72,79,84], which is evident in the analysis of data from the BEAT AML and TARGET studies using the UCSC Xena platform (https://xenabrowser.net/ accessed on 22 February 2025) (Figure 2) [85,86,87]. The gene discussed is ALDH1A1; the disease is acute myeloid leukemia.