IDH2 and neoplasm: Although the difference was not statistically significant, the proportion was higher in cluster A. This finding is consistent with the greater TIL infiltration observed in cluster A. Nonetheless, the overall prognosis of the IDH-wildtype group remained poorer than that of the IDH-mutant group, implying that the presence of tumor-reactive TILs alone is insufficient to overcome the immunosuppressive tumor environment.