APP and Alzheimer disease: Sarti et al. also found that the symbiotic treatment with (a multi-extract of fibers and plant complexes, containing inulin/fruit-oligosaccharides) and probiotics (a 50%–50% mixture of Lactobacillus rhamnosus and Lactobacillus paracasei) could attenuate pathological features of AD, including the neuronal degeneration, Aβ deposition and neuritic plaques, and the shrinkage in the cortex of APP/PS1 mice by reducing GFAP expression and microglia activation [140].