Zhu et al. found that the dietary intervention with KD in a LPS-induced rat PD model could reverse the disease progression by preventing certain events, including overexpression of pro-inflammatory mediators (TNF-α, IL-1β, and IL-6), the loss of dopaminergic neurons, and diminishing mGluR5+ microglia cells, elevating TSPO+ microglia cells, decreasing H3K9 acetylation in the mGluR5 promoter region and mGluR5 mRNA expression, and reducing the phosphorylation levels of Akt/GSK-3β/CREB pathway [190]. Here, GRM5 is linked to Parkinson disease.