To assess the functional relevance of CD36 in EP4MKO-induced atherosclerosis, ApoE−/−EP4Flox and ApoE−/−EP4MKO mice were fed a Western diet for 12 weeks in vivo, followed by their being intraperitoneally injected with Sulfosuccinimidyl oleate sodium (SSO, CD36 inhibitor) or saline for an additional 4 weeks. This evidence concerns the gene CD36 and atherosclerosis.