SQSTM1 and rheumatoid arthritis: Furthermore, the anti-rheumatic compound Sinomenine induces phosphorylation of p62 at Ser351(Ser349 in human) and Thr269/Ser272 sites in rheumatoid arthritis synovial fibroblasts, which activates Keap1-Nrf2 signaling to enhance its anti-arthritic effects [151].