PRKN and Sepsis: Meanwhile, the PINK1/PARK2 pathway in renal cells recruits and phosphorylates to activate the E3 ligase activity of PARK2 through PINK1, prompting the ubiquitination labeling of damaged mitochondria and their phagocytosis and degradation by autophagosomes, alleviating sepsis-related AKI through mitophagy [80].