Its core pathological feature is the dysregulation of the host immune response triggered by infection, manifested as a dynamic imbalance between early excessive inflammation, such as the tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) storms, and late immunosuppression, such as T cell exhaustion, ultimately leading to multiple organ dysfunction syndrome (MODS) [6]. Here, IL6 is linked to infection.