TGFB1 and thoracic aortic aneurysm: Furthermore, Da et al. demonstrated that AGGF1 enhances the interaction between its receptor, integrin α7, and LAP-TGF-β1, preventing LAP-TGF-β1 cleavage into its mature form, and this interaction suppresses Smad2/3 and ERK1/2 phosphorylation in VSMCs, mitigating thoracic aortic aneurysm progression [128].