LRP1 and aneurysm: Additionally, Au and Dianaly observed that mice lacking low-density lipoprotein receptor-associated protein 1 (LRP1) exhibited aortic dilation and reduced vascular responsiveness to vasoconstrictors—including norepinephrine, U-46619 (a thromboxane receptor agonist), elevated potassium, and decreased L-type calcium release—indicating that LRP1 regulates VSMC contraction by modulating calcium signaling and thereby plays a protective role in preventing aneurysm development [56].