These include the endogenous inhibitor of nitric oxide (NO) synthase, asymmetric dimethyl-arginine (ADMA), considered as a marker of endothelial dysfunction and CVD risk [13,14,15], and inflammatory cytokines such as tumor necrosis factor-α (TNF-α), which is associated with vascular pathophysiology [16,17]. The gene discussed is TNF; the disease is endothelial dysfunction.