Furthermore, despite the reported relationship of ADMA concentrations with worse renal function in elderly people [45] and poor prognosis in chronic kidney disease [46] as well as the increase in TNF-α in patients with diabetic nephropathy [47], Orai1 was the only donor biomarker able to predict worse renal function in the kidney recipients up to 6 months after transplantation. The gene discussed is TNF; the disease is diabetic kidney disease.