It has been established that the accumulation of DAG was associated with insulin resistance in various tissues, including the liver and skeletal or cardiac muscles, due to the activation of protein kinase C θ (PKCθ), which in turn blocks IRS, inhibits the activation of the Akt pathway and results in lowering the insulin-stimulated glucose uptake to the cells [49,50,51]. This evidence concerns the gene IARS1 and Insulin resistance.