CEACAM5 and colorectal cancer: Hombach and co-workers demonstrated that co-culturing anti-carcinoembryonic antigen (CEA)-specific CAR-expressing T cells with CEA-positive LS174T colorectal cancer cells in the presence of IL-7/IL-12-engineered MSCs produced significantly higher amounts of pro-Th1 inflammatory cytokines IFN-γ and TNF-α [28].