Furthermore, MSCsGD2-TRAIL released sTRAIL that induced apoptosis in GD2-expressing ES cells more efficiently than recombinant human TRAIL (rhTRAIL), underscoring the advantages of using MSCsGD2-TRAIL for sustained delivery of sTRAIL in a tumor microenvironment of GBM, ES, and other GD2-expressing malignancies [41]. This evidence concerns the gene TNFSF10 and neoplasm.