FL118 inhibits Survivin and Mcl-1 by selectively suppressing their gene transcription and promoting proteasome-mediated degradation, thereby disrupting their ability to inhibit caspase activation and neutralize pro-apoptotic proteins, ultimately restoring the apoptotic sensitivity of MM cells to CAR T cell-mediated killing [26,28]. This evidence concerns the gene BIRC5 and Miyoshi myopathy.