KCNA3 and Huntington disease: In addition to brain dysfunction, HD is known to cause: (i) skeletal muscle impairments, associated with chloride and potassium channel dysfunction, resulting in muscle hyperexcitability, hypertonicity, twitching, and atrophy [70,71,72,73]; (ii) ocular alterations, including retinal nerve fiber layer thinning [74,75,76,77,78]; (iii) bone marrow disruption; (iv) immune system dysregulation, leading to platelet abnormalities [76] and increased production of pro-inflammatory cytokines [79].