PRTN3 and rheumatoid arthritis: Analyzing clinical and inflammation measures at the first visit, we found that MTX non-responders had a higher RA classification score (Figure 1A) with higher swollen joint counts (Figure 1B), and a higher frequency of RF and ACPA (Figure 1C), while the absolute levels of inflammation parameters were comparable between MTX responders and MTX-non-responders (Figure 1D–G).