C9orf72 and amyotrophic lateral sclerosis: By filtering for p-value adj ≤ 0.05 and |log2FC| > 2, when comparing each ALS iPSC with the healthy controls, we obtained 234 DEGs (41 upregulated and 194 downregulated genes) for ALS001_KIF5A (Figure 4A); 1001 DEGs (443 upregulated and 558 downregulated genes) for ALS002_TARDBP (Figure 4B); 171 DEGs (98 upregulated and 73 downregulated genes) for ALS003_C9orf72 (Figure 4C); and 444 DEGs (252 upregulated and 192 downregulated genes) for ALS004_TARDBP (Figure 4D).