Of note, IL-17A is involved in the late remodelling stages after MI by promoting an infiltration of neutrophils and macrophages and an upregulation of pro-inflammatory cytokines and, in comparison with their wild-type littermates, IL-17A-deficient mice demonstrate an improved survival and attenuated LV dilation 28 days post MI [24]. This evidence concerns the gene IL17A and myocardial infarction.