Based on our previous results, considering the ability of oligodendrocytes (OLs) to respond to neuroinflammatory environments occurring in the nervous system during neurodegenerative and demyelinating diseases and considering the sensitivity of OLs to oxidative agents present as products of neuroinflammation, we tested the protective role of α7 nAChR for OLs. Here, CHRNA7 is linked to demyelinating disease.