Although OECM1 cells retain key properties of the oral epithelium (grow in tight sheets, and MxA is induced in these cells by IFN-λ1, a Type III interferon, but not by IFN-α2, a Type I interferon [48]), a next step would be to include additional oral cancer cell lines and to also evaluate primary human gingival or immortalized gingival cell lines in these investigations. Here, MX1 is linked to lip and oral cavity carcinoma.