To date, only Tissino et al. have demonstrated that EMILIN-1 triggers pro-survival signaling in chronic lymphocytic leukemia (CLL) cells through its specific interaction with the α4β1 integrin, as evidenced by enhanced ERK and AKT phosphorylation and reduced apoptosis in-vitro [20]. Here, EMILIN1 is linked to B-cell chronic lymphocytic leukemia.