ENL itself displays oncogenicproperties. Genomic analysis shows thatENL associates with a broader set ofgenes compared with MLL-fusion proteins in leukemia cell lines MOLM-13and MV4-11, suggesting a more widespread role in transcriptional regulation.The genes bound by ENL in leukemia are enriched in pathways implicatedin blood cancer and hematologic diseases. Here, KMT2A is linked to leukemia.