To date, three distinct scaffolds, SR-0813, SGC-iMLLT,and PFI-6, have been utilized to generate PROTAC molecules capableof degrading ENL.,, These degraders, designed with either CRBN or VHL E3 ligase recruiters,suppress transcription of ENL target genes and demonstrate efficacyin mouse models of acute leukemia. The gene discussed is MLLT1; the disease is acute leukemia.