YEATS4 and non-small cell lung carcinoma: GAS41 depletion decreasestotal H2A.Z levels, despite unchanged expression of H2A.Z-encodinggenes, but restoration of H2A.Z levels does not rescue defects inchromatin loading, gene expression, or cell proliferation, revealinga critical role of GAS41 in enabling H2A.Z deposition at loci necessaryfor NSCLC cell survival. The defectscaused by GAS41 knockdown, including reduced H2A.Z protein levelsand impaired cell growth, were reversed by the reintroduction of wild-typeGAS41 but not by the reintroduction of the mutants deficient in acyllysinebinding.