Based on bioinformatics analysis, He et al. reported that Lrrc15 was highly expressed in the synovial tissues of patients with RA, and its expression was positively correlated with the number of follicular helper T cells and M1 macrophages, while it was negatively correlated with the number of monocytes and resting dendritic cells [19]. The gene discussed is LRRC15; the disease is rheumatoid arthritis.