We subsequently investigated (1) the effect of APOE ε4 allele on correlations between dynamic metrics and cognition, plasma AD biomarkers in AD; (2) the mediation effect of APOE ε4‐related alterations in dynamic metrics on the relationship between Aβ pathology and cognitive function; (3) the diagnostic performance of combined models in identifying AD patients. The gene discussed is APOE; the disease is Alzheimer disease.