Critically, we observed negative associations between voxel‐wise concordance in the right CAU and MMSE scores (R = −0.303, p = 0.017, Figure 3a), MoCA scores (R = −0.304, p = 0.029, Figure 3b), attention (R = −0.314, p = 0.037, Figure 3c), language function (R = −0.317, p = 0.039, Figure 3d), orientation function (R = −0.346, p = 0.039, Figure 3e) but a positive association with plasma Aβ42 (R = 0.297, p = 0.025, Figure 3f) in APOE ε4 carriers with AD rather than non‐carriers. Here, APOE is linked to Alzheimer disease.