Additionally, eight were syndromic patients: four with Noonan syndrome (PTPN11 and biallelic LZTR1), two with Danon disease (LAMP2), two with Carvajal syndrome (DSP), and one with atypical glycogen storage disease (PRKAG2). Here, PTPN11 is linked to arrhythmogenic cardiomyopathy with wooly hair and keratoderma.