DYSF and acute myeloid leukemia: Additionally, dysferlin's role in intracellular signaling (e.g., calcium flux modulation) may indirectly influence apoptosis resistance, a hallmark of AML persistence,[34] and could be used as a prognostic biomarker to predict survival in patients with renal cell carcinoma.[35] Meanwhile, MAFB is a transcription factor essential for myeloid differentiation, particularly in monocyte/macrophage lineage commitment.