BRCA1 and serous adenocarcinoma: Perets et al. (2013) showed that inactivation of Brca1/2, Trp53 and Pten in Pax8-expressing murine tubal secretory cells induced serous tubal intraepithelial carcinoma (STIC) lesions. Over time, the STIC lesions advanced to aggressive tumors that spread to the ovary and peritoneum (Perets et al., 2013). Similarly, genetic inactivation of various combinations of Brca1, Trp53, Rb1 and Nf1 in Ovgp1-expressing tubal epithelial cells leads to high-grade serous carcinomas that arise in the mouse oviduct (Zhai et al., 2017).