CCNE1 and ovarian cancer: However, among the overlapped DE genes, we identified upregulation of genes encoding several markers typically overexpressed in ovarian cancer: cyclin E1 (Ccne1) (Karst et al., 2014), RAD51-associated protein 1 (Rad51ap1) (Filipe et al., 2022), osteopontin (Spp1) (Kim et al., 2002) and its signaling receptor, Cd44 (Sliutz et al., 1995) (Fig. 4D).