GH1 and obesity due to melanocortin 4 receptor deficiency: According to the study, a higher cumulative incidence of CVRF clusters over time was linked to raised blood pressure, hyperglycemia, low HDL, hypertriglyceridemia, and obesity. The likelihood of developing a CVRF cluster was linked to factors such as growth hormone deficit, cranial radiation history, and grade II-IV acute GVHD.