It is primarily an autoimmune disease mediated by circulating autoantibodies targeting podocyte-expressed antigens such as phospholipase A2 receptor (PLA2R), thrombospondin type-1 domain-containing 7A (THSD7A), and neural epidermal growth factor-like 1 protein (NELL-1). The gene discussed is THSD7A; the disease is autoimmune disease.