HOTAIR single-nucleotide polymorphisms (SNPs) have been studied as potential cancer susceptibility sites and have been associated with an increased risk of human cancers, such as breast cancer (BC) [5–7], esophageal squamous cell carcinoma [1], stomach cancer [8], lung cancer [9], and colorectal cancer [10]. Here, HOTAIR is linked to esophageal squamous cell carcinoma.