Our meta-analysis showed that homozygous (TT vs. CC: OR = 1.337, 95% CI: 1.001–1.786), dominant (CT + TT vs. CC: OR = 1.076, 95% CI: 1.026–1.1280), recessive (TT vs. TC + CC: OR = 1.293, 95% CI: 1.058–1.580), and additive (T vs. C: under the OR = 1.150, 95% CI: 1.021–1.295) genetic models and HOTAIR rs920778 gene mutation revealed an increased risk of cancer in Asian populations but no significant association in Caucasian populations. Here, HOTAIR is linked to cancer.