CRP and obesity due to melanocortin 4 receptor deficiency: They also exhibited a greater prevalence of metabolic abnormalities, including elevated C-reactive protein (0.44 vs. 0.36 mg/dL, P < 0.001), insulin resistance (HOMA-IR >2.5: 51.6 % vs. 22.3 %, P < 0.001), and multiple components of CKM syndrome, such as obesity, central obesity, hypertension, diabetes, and metabolic syndrome (Table 2).