CISH and pulmonary fibrosis: In line with this, our mRNA-miRNA interaction network predicts that all subtypes of miR-30 (miR-30a-5p, miR-30b-5p, miR-30c-5p, miR-30d-5p, and miR-30e-5p) regulate SOCS3. Functionally, the SOCS domain inhibits fibronectin and collagen matrix assembly, reduces α-SMA levels, and mitigates matrix deposition in lung fibroblasts and experimental pulmonary fibrosis (Magdaleno et al., 2024).