STAT3 and central nervous system cancer: Notably, overexpression of miR-30 is observed in glioma stem cells; downregulation of miR-30 reduces SOCS3 suppression, activating the JAK/STAT3 signaling pathway, thus confirming the regulatory role of the miR-30/SOCS3/JAK/STAT3 axis (Che et al., 2015).