Interestingly, hub genes of Visual Cortex-ME6 were mainly transcriptional regulators, such as Dnaja2 and Vsp35,36,37 as well as nervous system development regulators, such as Pfn2. 38Of interest, Dnaja2 is also shown to play a protective role against tau aggregation in AD37,39,40 and Vsp35 has shown to be associated with late onset Parkinson disease.41 Here, MAPT is linked to Parkinson disease.