Inhibiting this lateralization or blocking the activity of Cx43 hemichannels or expressing a mimicked-phosphorylated Cx43 all prevent ISO-stimulated ventricular arrhythmia and death in mdx mice (Gonzalez et al., 2015; Himelman et al., 2020; Lillo et al., 2019). The gene discussed is GJA1; the disease is Ventricular arrhythmia.