INS and prediabetes syndrome: A post hoc analysis of data from the Pathobiology of Prediabetes study in a bi-racial cohort showed that baseline HSI was associated with insulin sensitivity (r = −0.44, p < 0.0001), high-sensitivity C-reactive protein (r = 0.37, p < 0.0001) and adiponectin (r = −0.24, p < 0.0001) (45).